与双相情感障碍相比,精神分裂症中腹部条纹体的过度活动和功能连接性发生变化:静止状态fMRI研究
Li Zhang1, Wenli Wang2, Yuan Ruan2
1Affiliated Psychological Hospital of Anhui Medical University, Hefei, Anhui Province, China; Anhui Mental Health Center, Hefei, Anhui Province, China; School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, 230032, China; Laboratory of Neuromodulation, Anhui Mental Health Center, Hefei, Anhui Province, China; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei 230022, China.
精神分裂症与腹部条纹体 (VS) 功能障碍有关,特别是在双边下层VS (VSi). 在VS激活和连接的异常与患者的症状严重程度相关.
科学领域:
- 神经成像是一种神经成像.
- 精神病学是一个精神病学.
- 脑部成像 脑部成像
背景情况:
- 腹腔条纹体 (VS) 异常在精神分裂症中很常见.
- 了解VS功能障碍是精神分裂症研究的关键.
研究的目的:
- 研究精神分裂症中VS子区域内的基底激活和功能连接 (FC).
- 为了比较精神分裂症 (SCH),双相情感障碍 (BD) 和健康对照 (HCs) 的VS功能.
主要方法:
- 使用了休息状态功能磁共振成像 (fMRI).
- 分析了62名SCH,57名BD患者和26名HC患者的4个VS亚区域.
- 低频波动 (fALFF) 和FC的检查的分数振幅.
主要成果:
- 精神分裂症患者在双边VS子区域的fALFF比BD和HC组更大.
- 在SCH中,在双边下方VS (VSi) 和诸如乳头,面,PCC,前皮层和尾状皮层等区域之间观察到增加的FC.
- 双边VS中的fALFF与阳性症状严重程度正相关.
- 双边VSi和某些大脑区域之间的FC与负症状严重程度正相关.
结论:
- 腹腔条纹体功能障碍,特别是在双边的VSi,显着导致精神分裂症.
- 功能上不同的VS区域在精神分裂症中表现出差异性障碍.
- 这些发现强调了VSi在精神分裂症病理生理学中的关键作用.
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