训练有素的先天免疫:概念,命名和未来的前景
Mihai G Netea1, Leo A B Joosten2
1Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands; Department for Immunology and Metabolism, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.
天生的免疫细胞可以通过代谢和表观遗传变化发展记忆,称为训练免疫. 这种现象影响疾病,并提供新的疫苗和治疗策略.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 疾病的病原发生 疾病的病原发生
背景情况:
- 天生的免疫细胞传统上缺乏适应性特征.
- 最近的证据表明,先天性免疫细胞可以产生长期的功能变化,称为训练免疫.
- 训练有素的免疫包括代谢重新连接和表观遗传修饰.
研究的目的:
- 探索训练免疫的概念和影响.
- 讨论训练免疫在人类疾病中的作用.
- 突出训练免疫的潜在治疗和预防应用.
主要方法:
- 关于先天免疫记忆的累积证据的审查.
- 分析培训免疫的基础机制 (代谢和表观遗传).
- 检查训练免疫在感染,炎症和神经退行症中的作用.
主要成果:
- 训练有素的免疫力在疫苗诱导时给予异种保护,防止感染.
- 失调的训练免疫力有助于炎症和神经退行性疾病.
- 训练有素的免疫力为新型疫苗和治疗开发提供了机会.
结论:
- 训练有素的免疫代表了理解免疫反应的重大进步.
- 利用训练有素的免疫力可能会导致下一代疫苗具有更高的疗效.
- 调节训练免疫力为癌症和炎症性疾病提供了新的治疗途径.
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