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Updated: Jun 13, 2025

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
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Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation

Published on: May 20, 2020

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设计和活动评估新EGFR氨酸激酶抑制剂含有循环聚氨酸的EGFR氨酸激酶抑制剂

Liang-Liang Guo1, Yan-Hong Zhang2, Jun-Fang Zuo1

  • 1Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.

Bioorganic & medicinal chemistry letters
|September 15, 2024
PubMed
概括

开发了针对耐药性非小细胞肺癌 (NSCLC) 的新EGFR抑制剂. 虽然对三重突变EGFR表现出适度的活动,但化合物b为优化未来NSCLC治疗提供了洞察力.

关键词:
第四代EGFR技术技能减少ATP的使用.这是C797S突变.在NSCLCLC中,我们可以看到.聚氨酸是一种多氨酸.基纳林衍生物 基纳林衍生物

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Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib

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