身体组成的变化和肝脏疾病严重程度之间的长度联系在患有代谢功能障碍相关的脂肪性肝病的儿童和青少年中
Alexandria Speakman1, Kathryn Hitchcock2, Emily Romantic2
1Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; University of Cincinnati College of Medicine, Department of Pediatrics, Cincinnati, OH.
减少脂肪质量,而不是肌肉,与在患有代谢功能障碍相关的脂肪性肝病 (MASLD) 的儿童中改善肝脏健康标志物有关. 脂肪质量变化比BMIz-score更好地预测MASLD回归.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 在儿童中越来越普遍.
- 在儿童群体中,人体构成的纵向变化及其对MASLD严重程度的影响尚未得到充分理解.
研究的目的:
- 检查儿科MASLD中身体组成的纵向变化与肝病严重程度之间的关联.
- 为了确定脂肪质量或骨肌肉质量的变化是否预测MASLD回归.
主要方法:
- 对患有MASLD的儿科患者 (20岁以下) 的回顾性分析.
- 利用生物电阻分析 (BIA) 来评估随时间推移的身体组成.
- 采用了逻辑和线性回归来将身体组成的变化与肝酶水平和MASLD回归相关联.
主要成果:
- 减少脂肪质量指数独立地与较低的ALT和胺转移酶水平相关.
- 减少脂肪质量指数显著增加了MASLD回归的几率.
- 骨肌肉质量指数的变化与肝酶变化无关.
结论:
- 脂肪质量减少,而不是骨肌肉质量变化,与儿科MASLD中肝损伤的血清学标志物改善有关.
- 脂肪质量指数的变化是MASLD回归的更强的预测因素,而不是BMIz-score的变化.
- 生物电阻分析 (BIA) 显示了作为监测年轻人肝病进展的辅助生物标志物的潜力.
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