相关实验视频

Updated: May 5, 2026

Removal of Trace Elements by Cupric Oxide Nanoparticles from Uranium In Situ Recovery Bleed Water and Its Effect on Cell Viability

Removal of Trace Elements by Cupric Oxide Nanoparticles from Uranium In Situ Recovery Bleed Water and Its Effect on Cell Viability

Published on: June 21, 2015

在西班牙的NELA队列中的婴儿断奶期间,非必需元素和必需元素的尿度

Leyre Notario-Barandiaran¹, Eva Morales², Jesús Vioque³

¹Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.

Environmental research

|September 15, 2024

概括

婴儿对必要和非必要元素的暴露在断奶期间发生显著变化. 母乳养的婴儿暴露率较低,而固体食物增加了和等元素的摄入量.

科学领域:

环境健康环境健康
儿童营养学儿童营养学
毒理学毒理学毒理学

背景情况:

婴儿期是一个关键的发育时期,暴露在元素中可能会对健康产生持久的影响.
了解奶期间对必需和非必需元素的内部暴露对于婴儿健康至关重要.
早期生命和喘中的营养 (NELA) 出生队列为这项研究提供了有价值的数据.

研究的目的:

评估尿液中基本元素和非基本元素的度,作为3至18个月龄的婴儿内部暴露的代理.
为了比较纯母乳养的婴儿和养配方奶粉或混合饮食的婴儿之间的元素暴露.
为了确定影响断奶期间元素暴露的饮食因素.

主要方法:

分析了490名3个月大的婴儿和216名18个月大的婴儿的社会人口统计,饮食和尿液元素数据.
来自175名婴儿的配对尿样被分析为必需的 (Co, Cu, Mo, I, Fe, Mn, Se, Zn, Ni) 和非必需的 (Al, V, As, Cd, Sb, Tl, Pb) 元素.
不同养群体之间的元素度的比较以及3至18个月的年龄段.

主要成果:

纯母乳养的婴儿在3个月后尿液中Al,V,Fe,Co,Se,Sb和Tl的度较低.
与母乳养的婴儿相比,配方奶粉养的婴儿显示出明显更高的 (Mo) 度.
在3至18个月之间,尿液中As,Co,Mo,Pb,Se,Tl和V的度增加,而铜 (Cu) 的度下降.
引入包括白鱼,大米,意大利面和豆类在内的固体食品,与增加对As,Pb和Mo等元素的暴露有关.

结论:

母乳养与婴儿早期对非必需元素的暴露较低有关.
固体食品的引入大大改变了婴儿对基本和非基本元素的暴露.
断奶期间监测元素暴露很重要,特别是对于和等元素,这些元素随着固体食物消费而增加.

关键词:

哺乳期哺乳期哺乳期饮食饮食饮食饮食环境暴露环境暴露婴儿时期的婴儿时期对金属的暴露金属的暴露过渡过渡过渡过渡

更多相关视频

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis

Published on: February 9, 2021

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

相关概念视频

Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations

Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations

Gentamicin, an aminoglycoside antibiotic, is commonly administered via intermittent intravenous infusion to treat severe infections. An intermittent one-hour infusion of gentamicin, administered at eight-hour intervals, allows for precise control of plasma drug concentrations, minimizing toxicity while ensuring therapeutic efficacy. Pharmacokinetic principles govern the dynamics of plasma concentrations and can be mathematically described using specific equations.The plasma drug concentration...

Pharmacokinetics in Pediatric Patients: Drug Distribution

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...

Pharmacokinetics in Pediatric Patients: Drug Excretion

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...

Physiology of the Genitourinary System III: Urine Concentration and Dilution

Physiology of the Genitourinary System III: Urine Concentration and Dilution

The kidneys concentrate or dilute urine to maintain water and electrolyte balance. Nephrons, particularly the loop of Henle, play a crucial role in this process through the countercurrent multiplication system. This system establishes a high osmolarity in the renal medulla, which is essential for water reabsorption. In the loop of Henle’s descending limb, water is reabsorbed into the surrounding medulla due to its permeability to water. In contrast, the ascending limb actively transports...

Urinary Tract Calculi IV: Nutrition Therapy and Prevention

Urinary Tract Calculi IV: Nutrition Therapy and Prevention

Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...

Serum Studies: Renal Function Tests

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.