提高了用于初级包装的玻璃瓶的性能,其中包括原子层沉积
Ilkka Manninen1, Riina Ritasalo1, Samuli Hirsjärvi2
1Picosun Oy, an Applied Materials company, Masalantie 365, 02430 Masala, Finland.
Journal of pharmaceutical sciences
|September 15, 2024
概括
原子层沉积 (ALD) 在玻璃瓶上创建纳米尺度的保护膜,防止药物产品被提取物和可浸出物污染. 这些先进的涂层提高了包装的性能和稳定性.
科学领域:
- 材料科学 材料科学 材料科学
- 药品包装 药品包装 药品包装
- 表面工程是什么?表面工程是什么?
背景情况:
- 药品包装需要先进的材料来防止与敏感药品的相互作用.
- 可提取和可浸出物对药物的稳定性和安全性构成风险.
- 现有的包装材料可能无法满足新药的严格性能要求.
研究的目的:
- 调查原子层沉积 (ALD) 的应用,以增强初级药品包装.
- 评估ALD涂层玻璃瓶的屏障特性和功能修改.
- 评估ALD薄膜对可提取物,可浸物和水解耐药性的影响.
主要方法:
- 使用ALD将SiO2,ZrO2和Al2O3-TiO2纳米尺度的薄膜沉积在I型玻璃玻璃瓶上.
- 用ALD涂层的瓶子与未涂层的对照组进行了比较.
- 进行了水解电阻,水导率和可提取/可泄漏分析.
主要成果:
- ALD涂层显著提高了85-92%的水解电阻.
- 与未涂层的瓶子不同的是,没有检测到有稳定的ALD膜的瓶子中提取的元素.
- 阿尔德薄膜为提取物和漏物提供了屏障,增强了表面完整性.
- ALD涂层允许调节的紫外线阻断,而不影响透明度和增加表面的水友性.
结论:
- ALD是一种多功能技术,用于在初级包装材料上创建高性能屏障和功能薄膜.
- ALD涂层有效地防止药物产品被可提取物和可浸物污染.
- ALD技术为改善药品包装稳定性和安全性提供了一条途径.
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