食物过敏在亚托匹性皮肤炎中的作用
Brit Trogen1, Megha Verma2, Scott H Sicherer1
1Division of Pediatric Allergy, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, NY 10029, USA.
Dermatologic clinics
|September 15, 2024
概括
患有严重的亚托皮性皮肤炎 (AD) 的婴儿面临更高的食物过敏的风险. 然而,在患有阿尔茨海默症的儿童中,阳性血清免疫球蛋白E (IgE) 测试并不总是证实临床食物过敏.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 儿科皮肤病学 儿科皮肤病学
- 临床营养学 临床营养学
背景情况:
- 亚托皮炎 (AD) 和食物过敏是儿童常见的疾病.
- 它们的共同发生和关系是复杂的和争论的.
- 早期的AD,尤其是严重的病例,与增加的食物过敏风险有关.
研究的目的:
- 在生命早期探索亚托皮性皮肤炎和食物过敏之间的复杂关系.
- 为了澄清阿托皮性皮肤炎严重程度对发展食物过敏的预测价值.
- 在这种情况下,评估血清免疫球蛋白E (IgE) 测试的诊断效用.
主要方法:
- 对有关亚托皮性皮肤炎和食物过敏的现有文献的审查.
- 对研究早期阿尔茨海默症作为食物过敏风险因素的研究分析.
- 检查了与AD儿童临床食物过敏相关的血清IgE敏感性数据.
主要成果:
- 婴儿/幼儿时期严重的亚托皮炎是IgE介导食物过敏的重要危险因素.
- 许多患有阿兹海默症的儿童通过血清IgE测试对多种食物产生敏感性.
- 血清IgE敏感性并不总是等同于临床的食物过敏诊断.
结论:
- 早期和严重的亚托皮性皮肤炎是潜在的食物过敏发展的关键指标.
- 临床评估至关重要,因为单独的血清IgE测试可能会高估AD患者的食物过敏.
- 了解这种联系有助于早期诊断和治疗亚托皮性疾病.
相关概念视频
Allergic Reactions
27.3K
Overview
27.3K
Allergic Drug Reactions
821
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
821
Hypersensitivities
556
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
556
Antibody Structure
59.6K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
59.6K
Cross-reactivity
31.0K
Overview
31.0K
Asthma: Pathogenesis and Management
371
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
371


