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Updated: Jun 13, 2025

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蛋白质组学揭示了从胎儿到成年期的人类造血干细胞的动态代谢变化

Mingfang Xiong1,2, Yanyu Xiu1,3, Juan Long1

  • 1Senior Department of Hematology, the Fifth Medical Center of Chinese PLA General Hospital, Beijing, 100071, China.

Stem cell research & therapy
|September 15, 2024
PubMed
概括

人类造血干细胞 (HSPCs) 在发育过程中从氧化代谢转变为糖溶性代谢. 这项研究揭示了HSPCs在胎儿,带血和成人阶段的关键代谢和免疫类型变化.

关键词:
成年人骨髓 (aBM) 是指成人的骨髓.胎儿肝脏 (FL) 是指胎儿的肝脏.谷氨 (GSH) 是一种造血干细胞 (HSPCs) 的前代细胞.代谢重塑是指新陈代谢的重塑.蛋白质组学是指蛋白质组学.带血液 (UCB) 是指带血的部分.

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