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MBV-Pipe:一站式工具箱,用于评估老鼠大脑的形态变化,用于跨度研究.

Wentao Jiang1,2, Xinyi Liu1, Ming Song3,4

  • 1Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.

Neuroinformatics
|September 15, 2024
PubMed
概括

鼠标大脑成像显示 perfusion 后显著的体积变化,但白质完整性保持稳定. 这项研究介绍了MBV-Pipe,这是一个新的工具箱,用于在样本准备过程中分析小鼠大脑形态.

关键词:
跨度尺度的跨度尺度.处理MRI数据处理MRI数据处理形态学 形态学 形态学鼠标大脑 鼠标大脑开发工具箱开发工具箱

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科学领域:

  • 神经科学是一个神经科学.
  • 生物医学成像技术 生物医学成像技术
  • 计算生物学 计算生物学

背景情况:

  • 鼠标模型对于神经科学研究至关重要.
  • 样本准备用于脑成像可以改变形态,造成差异.
  • 缺乏可访问的工具箱阻碍了对小鼠大脑形态变化的评估.

研究的目的:

  • 开发一种可访问的工具箱,用于处理小鼠大脑MRI数据.
  • 评估样本准备过程中的形态和白质完整性变化.
  • 为了验证开发的工具箱的可靠性.

主要方法:

  • 开发小鼠大脑体积统计数据管道 (MBV-Pipe) 工具箱.
  • 通过指数化的谎言代数 (DARTEL) -基于Voxel的形态学 (VBM) 和基于通道的空间统计 (TBSS) 集成不同形态的解剖学注册.
  • 使用9.4TMRI系统在三个时间点 (体内,输液后,固定后) 获取小鼠大脑MRI数据.

主要成果:

  • 与体内相比,MBV-Pipe在输液后发现了大量体积变化.
  • 固定只引发了微小的体积变化.
  • 在所有准备阶段,白质完整性在很大程度上保持稳定.

结论:

  • 在样本准备过程中,MBV-Pipe可靠地量化了小鼠大脑的形态变化.
  • 该工具箱有助于优化小鼠大脑研究的实验协议.
  • MBV-Pipe是公开提供GUI,促进更广泛的采用和可重复性.