评估最低报告限制,以确定在竞争中使用刺激剂
Vinod S Nair1, Fatjon A Hanelli1, Chad Moore1
1Sports Medicine Research and Testing Laboratory, South Jordan, Utah, USA.
Drug testing and analysis
|September 15, 2024
概括
尿液最低报告限值 (MRL) 可能无法可靠地区分在比赛中的兴奋剂使用. 在多种样本类型中,在药物停止后很长时间内,分析物的度仍然可以检测到.
科学领域:
- 在体育运动中的兴奋剂控制.
- 药理动力学和新陈代谢
- 分析化学是一种分析化学.
背景情况:
- 尿液最低报告限值 (MRL) 用于检测运动员的禁止物质.
- 由于剂量变化和未知的药理相关性,MRL适用于确定竞争中兴奋剂的使用是有争议的.
- 当前的MRL可能不准确地反映了比赛期间的药物使用情况.
研究的目的:
- 评估尿液MRL是否能区分激励剂的竞赛和非竞赛使用.
- 为了评估安非他胺,甲基酸盐和莫达菲尼尔在受控剂量后在各种生物矩阵中的检测能力.
- 为了研究不同矩阵中的分析物度在冲洗期间的相关性.
主要方法:
- 一个受控的管理研究,涉及四到六名志愿者.
- 连续五天每天服用安非他胺,甲基酸或莫达菲尼尔,以低剂量治疗.
- 在服药期间和停止后48小时内收集尿液,血清,干血斑 (DBS) 和口液 (OF).
- 分析所有收集的矩阵中的分析物度的分析.
主要成果:
- 在所有参与者中,所有目标分析物的尿度在戒药后48小时内都超过了MRL.
- 大多数志愿者在使用后48小时内在血清和DBS中发现了可检测量的兴奋剂.
- 尽管剂量相似,但峰值度在化合物之间有显著差异,并且度在矩阵之间没有一致的相关性.
- 口服液分析由于正常化问题而存在挑战.
结论:
- 尿液的MRL可能不足以最终确定竞争中兴奋剂的使用.
- 该研究强调了用于兴奋剂控制的生物样本中药物度的解释所面临的挑战.
- 需要进一步的研究来完善区分在比赛中和比赛之外使用毒品的方法.
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