风湿性关节炎中肺部参与和抗CCP抗体之间的联系是什么:一个横截面研究
Hind El-Kasmi1, Taoufik Harzy1, Nessrine Akasbi1
1Department of Rheumatology, Centre Hospitalier Universitaire Hassan II, BP:1835 Atlas, Fès, Avenue Hassan II, Fes 30050, Morocco.
Current rheumatology reviews
|September 16, 2024
概括
类风湿性关节炎 (RA) 患者具有阳性抗循环酸 (anti-CCP) 抗体,患肺部疾病的风险明显更高. 对这些人来说,早期监测肺部并发症至关重要.
科学领域:
- 类风湿病学 类风湿病学
- 肺部病理学 肺部病理学
- 免疫学 免疫学 免疫学
背景情况:
- 肺部干扰是风湿性关节炎 (RA) 中常见的关节外表现.
- 之前的研究表明,与RA相关的肺部疾病与抗循环化 (抗CCP) 抗体之间存在联系.
研究的目的:
- 为了确定RA患者肺部参与的患病率.
- 调查抗CCP抗体与RA中的各种肺部疾病之间的关联.
主要方法:
- 从2011年1月到2022年3月,对390名RA患者进行了回顾性观察性研究.
- 胸部高分辨率计算机断层扫描 (HRCT) 和抗CCP抗体状态的分析.
- 后勤回归模型用于评估关联并计算赔率比率 (OR).
主要成果:
- 14.4%的RA患者患有肺病,其中结节和间歇性肺病 (ILD) 是最常见的.
- 64.6%的患者检测出抗CCP抗体呈阳性.
- 阳性抗CCP抗体与肺部参与有显著的相关性 (OR = 5.25,p < 0.0001).
结论:
- 抗CCP抗体和肺部参与RA之间存在强烈的关联.
- 具有阳性抗CCP抗体的RA患者需要对肺部并发症进行警监测.
相关概念视频
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.7K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.7K
01:30Pneumonia III: Complications and Assessment
188
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
188
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
2.8K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.8K
01:20The JAK-STAT Signaling Pathway
8.7K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.7K