氧化多不和脂肪酸促进大肠炎和大肠炎相关瘤发生在小鼠中
Weicang Wang1,2, Yuxin Wang1,2, Katherine Z Sanidad1,3,4,5
1Department of Food Science, University of Massachusetts, Amherst, MA, USA.
Journal of Crohn's & colitis
|September 16, 2024
概括
氧化多不和脂肪酸 (PUFA) 通过影响肠道微生物群和托尔类受体4 (TLR4) 信号,使小鼠的炎症性肠病 (IBD) 和相关的结肠癌恶化. 无氧化PUFA没有促进结肠炎.
科学领域:
- 胃肠病学 胃肠病学
- 营养科学 营养科学
- 癌症研究 癌症研究
背景情况:
- 人类研究将高摄入多不和脂肪酸 (PUFA) 与增加炎症性肠病 (IBD) 风险联系起来.
- 氧化与未氧化PUFA在IBD发展中的作用尚不清楚.
- PUFA容易氧化,这引发了对它们对肠道健康的影响的问题.
研究的目的:
- 为了比较氧化和未氧化PUFA对IBD发展的影响.
- 研究氧化PUFA在结肠炎相关结直肠癌中的作用.
- 阐明肠道微生物群和托尔类受体4 (TLR4) 信号的参与.
主要方法:
- 使用小鼠模型治疗德克斯硫酸盐 (DSS) 诱导的结肠炎和IL-10淘汰诱导的结肠炎.
- 评估了氧甲/DSS诱导的结肠瘤发生在被食氧化或未氧化PUFA的小鼠中.
- 研究了肠道微生物群和TLR4信号在PUFA诱导作用中的作用.
主要成果:
- 氧化PUFA在小鼠中加剧了结肠炎的严重程度和相关的结肠瘤发生.
- 无氧化PUFA没有促进结肠炎.
- 氧化PUFA恶化了肠道屏障功能障碍,增加了细菌转移,其影响取决于TLR4和肠道微生物群.
结论:
- 氧化PUFA通过TLR4和肠道微生物群依赖的途径促进小鼠的结肠炎和瘤发生.
- 研究结果表明,需要重新评估氧化PUFA的食品行业标准和法规.
- 区分氧化和无氧化PUFA对于了解IBD和癌症风险至关重要.
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