在低剂量肺癌查中评估支气管切除症进展:频率和预测因素
Qiang Cai1,2, Natthaya Triphuridet1,3, Yeqing Zhu1
1Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY.
Journal of thoracic imaging
|September 16, 2024
概括
在低剂量CT查中,6.4%的参与者出现了支气管切除症的进展. 年龄,吸烟史和特定的CT发现预测了进展,强调了吸烟者的持续评估的必要性.
科学领域:
- 肺部病理学 肺部病理学
- 放射学 放射学是一门学科.
- 医学查 医学查
背景情况:
- 支气管切除与肺功能下降和心肺疾病死亡率增加有关.
- 早期检测和了解进展对于管理这种情况至关重要.
研究的目的:
- 为了确定低剂量计算机断层扫描 (CT) 查计划的参与者中支气管切除症进展或新发作的频率.
- 在这个队列中确定支气管切除症进展的预测因子.
主要方法:
- 从2010-2019年间的早期肺部和心脏行动计划 (ELCAP) 中分析了前性注册队列.
- 基线和随访低剂量CT扫描 (5年以上) 和医疗记录的审查.
- 后勤和多变量回归分析以确定相关因素.
主要成果:
- 在534名参与者中,随访时间超过5年,6.4%的人出现了进展或新发育的支气管切除症.
- 有意义的预测因素包括年龄,吸烟的年份,以及ELCAP支气管支气管缩评分组件 (支气管扩张的严重程度/程度,壁厚,粘膜损伤).
结论:
- 在2182名参与者中,大约有136人预计将根据观察到的速度进步.
- 由于吸烟者的风险增加,应报告支气管切除症.
- 在低剂量CT查期间的持续评估可以实现早期检测和干预.
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