从发病到恶性:胰腺癌及其免疫抑制微环境的共同演变

Filip Bednar1,2, Lee Y Olsen3, Marina Pasca di Magliano1,2,4

  • 1Department of Surgery, University of Michigan, Ann Arbor, Michigan.

Cancer research
|September 16, 2024
PubMed
概括

胰腺癌中的免疫微环境随着疾病的进展而发展,在致癌的早期建立了免疫抑制. 这项基础性研究揭示了从早期病变到恶性瘤的免疫动态.

相关概念视频

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K