高剂量或标准剂量流感疫苗在连续第二个流感季节的免疫性和反应性
Hannah Bahakel1, Andrew J Spieker2, Haya Hayek3
1Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, Ohio.
The Journal of infectious diseases
|September 16, 2024
概括
血造细胞移植 (HCT) 后第二年的一剂流感疫苗显示出与第一年两剂相比,免疫原性得到改善. 高剂量三价流感疫苗 (HD-TIV) 和标准剂量四价流感疫苗 (SD-QIV) 的反应性相似.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 儿科血液学 儿科血液学
背景情况:
- 儿童造血细胞移植 (HCT) 接受者面临流感感染的重大风险.
- 以前的研究表明,高剂量三价流感疫苗 (HD-TIV) 在HCT接种者中比标准剂量四价流感疫苗 (SD-QIV) 更具有免疫性.
研究的目的:
- 评估接种流感疫苗的免疫性和安全性在HCT后连续一个季节.
- 在两个接种疫苗的季节中,比较儿科HCT接种者的HD-TIV和SD-QIV.
主要方法:
- 一个HCT接种者的子队伍重新注册第二年接种疫苗.
- 在基线和疫苗接种后测量了血凝素抑制标位.
- 线性混合效应模型被用来比较疫苗组之间的免疫性和跨年.
主要成果:
- 在HD-TIV和SD-QIV群体中,2年一次剂量流感疫苗的免疫性比1年两次剂量更高.
- 几何平均折叠上升和调整几何平均比率在第二年得到了改善.
- 系统和注射部位反应的频率在SD-QIV和HD-TIV组之间是可比的.
结论:
- 在HCT后的第二年,一剂流感疫苗可能足够,在前一年的两剂计划之后.
- 无论是HD-TIV还是SD-QIV,都在第二年一次剂量,与第一年两次剂量相比,都显示出增强的免疫性.
- 流感疫苗接种方案可以优化为儿科HCT幸存者.
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