唐氏综合征儿童的发展里程碑
Nicole Baumer1,2,3, Rafael DePillis1, Katherine Pawlowski1
1Division of Developmental Medicine, Department of Pediatrics.
Pediatrics
|September 16, 2024
概括
这项研究为患有唐氏综合征的儿童建立了基于年龄的发育里程碑规范,帮助儿科医生进行查和指导. 这些发现支持对唐氏综合征患者的早期干预.
科学领域:
- 儿科 儿科 儿科
- 发展生物学 发展生物学
- 遗传学 是一个遗传学.
背景情况:
- 美国儿科学会建议对患有唐氏综合征的儿童进行预期指导.
- 现有的工具缺乏针对这一群体的具体发展规范.
- 准确的发育查对于早期干预至关重要.
研究的目的:
- 估计儿童和青少年唐氏综合征发育里程碑的年龄范围.
- 为儿科医生提供用于发育查的工具.
- 为患有唐氏综合征的儿童的家庭提供量身定制的指导.
主要方法:
- 从842名唐氏综合征患者 (2个月至24岁) 通过问卷收集数据.
- 分析了2018年3月至2023年3月期间在波士顿儿童医院唐氏综合症计划的2599次访问.
- 混合效应后勤回归用于确定25个发育里程碑的基于年龄的概率,按性别分层.
主要成果:
- 介绍了唐氏综合征患者关键发展里程碑 (学术,适应性,语言,运动) 的年龄规范.
- 为达到里程碑的75%概率计算的年龄.
- 将既定规范与一般人群的规范进行比较.
结论:
- 为临床医生和家庭提供关键的基于年龄的唐氏综合征发展里程碑规范.
- 支持改善发育查和预期指导.
- 旨在加强对患有唐氏综合征的儿童和青少年的照顾和支持.
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