焦点体积,声波辐射力,在两个传感器的制度压力在两个传感器制度
ArXiv
|September 16, 2024
概括
正对角聚焦超声波刺激 (TUS) 显著提高了深部大脑目标的空间分辨率. 这种新的方法可以通过局部声辐射力量实现精确的神经调制,提高神经疾病的治疗精度.
科学领域:
- 神经外科 神经外科
- 生物医学工程 生物医学工程
- 声学 声学 在声学方面
背景情况:
- 跨的聚焦超声波刺激 (TUS) 为神经疾病提供非侵入性神经调制.
- 深层大脑的目标需要高空间分辨率和周围组织的节省.
- 目前的TUS限制包括降低透深度,增加频率以获得更好的分辨率.
研究的目的:
- 为深层大脑目标开发一种具有更好的空间分辨率的TUS方法.
- 为了研究直角排列的传感器的声学特性和功能.
- 为了使TUS中更精确的神经调制和机械学研究成为可能.
主要方法:
- 使用了一对1MHz的直角排列的传感器.
- 产生局部静止波并分析声波辐射力 (ARF).
- 研究了从粒子运动和ARF中产生应变.
主要成果:
- 在空间分辨率方面实现了40倍的改进,目标体积为0.24 mm3.
- 证明了具有周期性压缩和张力区域的高度局部化的静止波.
- 展示了对目标施加选择性正或负压力的能力.
结论:
- 正角的传感器排列显著提高了TUS的空间分辨率和精度.
- 这种方法允许局部和定向的ARF应用,包括选择性压力控制.
- 扩大了TUS在更精细的分辨率下调查超声波-神经元相互作用机制的能力.
更多相关视频
10:39Fabrication and Characterization of Thickness Mode Piezoelectric Devices for Atomization and Acoustofluidics
Published on: August 5, 2020
6.8K
08:38Author Spotlight: Integration of Fiber Photometry and Focused Ultrasound Neuromodulation for Investigating Neural Modulation in Freely Moving Mice
Published on: September 6, 2024
1.2K
相关概念视频
Sound as Pressure Waves
2.4K
Sound waves, which are longitudinal waves, can be modeled as the displacement amplitude varying as a function of the spatial and temporal coordinates. As a column of the medium is displaced, its successive columns are also displaced. As the successive displacements differ relatively, a pressure difference with the surrounding pressure is created. The gauge pressure varies across the medium.
The pressure fluctuation depends on the difference in displacements between the successive points in the...
The pressure fluctuation depends on the difference in displacements between the successive points in the...
2.4K
Measurements of Strain
520
Strain quantifies the deformation of a material under force, typically measured as normal strain, which represents the change in length when compared with the original length. Electrical strain gauges are used for enhanced accuracy. These devices consist of a conductive wire mounted on a paper backing that adheres to the material's surface. These gauges operate on the piezoresistive effect, where the wire's electrical resistance changes in response to mechanical deformation. The strain...
520
Sound Waves: Resonance
2.6K
Resonance is produced depending on the boundary conditions imposed on a wave. Resonance can be produced in a string under tension with symmetrical boundary conditions (i.e., has a node at each end). A node is defined as a fixed point where the string does not move. The symmetrical boundary conditions result in some frequencies resonating and producing standing waves, while other frequencies interfere destructively. Sound waves can resonate in a hollow tube, and the frequencies of the sound...
2.6K
Design Example: Strain Gauge Bridge or Wheatstone Bridge
365
The utilization of strain gauges as transducers for converting mechanical strain into electrical signals is a common practice in various engineering applications. These strain gauges are frequently integrated into Wheatstone bridge circuits to accurately measure parameters such as force or pressure. Within this context, each element within the circuit exhibits a resistance that undergoes subtle variations when subjected to mechanical strain. The primary objective is to convert minuscule...
365
Relation between Poisson's ratio, Modulus of Elasticity and Modulus of Rigidity
253
Deformation occurs in axial and transverse directions when an axial load is applied to a slender bar. This deformation impacts the cubic element within the bar, transforming it into either a rectangular parallelepiped or a rhombus, contingent on its orientation. This transformation process induces shearing strain. Axial loading elicits both shearing and normal strains. Applying an axial load instigates equal normal and shearing stresses on elements oriented at a 45° angle to the load axis.
253
Sound Waves: Interference
3.7K
Sound waves can be modeled either as longitudinal waves, wherein the molecules of the medium oscillate around an equilibrium position, or as pressure waves. When two identical waves from the same source superimpose on each other, the combination of two crests or two troughs results in amplitude reinforcement known as constructive interference. If two identical waves, that are initially in phase, become out of phase because of different path lengths, the combination of crests with troughs...
3.7K
