流行病学,存活率和肝脏内胆管癌的新治疗方式
Yating Wang1, Yasir Alsaraf1, Sai Samyuktha Bandaru1
1Hematology and Oncology, Ascension Providence Hospital, Southfield, MI, USA.
Journal of gastrointestinal oncology
|September 16, 2024
概括
自2000年以来,肝脏内胆管癌 (iCCA) 的发生率大幅上升. 2010年后的生存率有所改善,与里程碑式的试验相吻合,但自那以后稳定了下来.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 胆道癌症 胆道癌症 胆道癌症
背景情况:
- 肝脏内胆管癌 (iCCA) 是一种罕见的癌症,发病率不断增加,预后不佳.
- 了解长期趋势对于患者的治疗结果至关重要.
研究的目的:
- 评估iCCA患者的20年发病率和生存趋势.
- 评估基准临床试验对iCCA存活率的影响.
主要方法:
- 使用了监测,流行病学和最终结果 (SEER) 数据库 (2000-2020).
- 根据年龄调整的发病率 (AAIR) 计算,并根据诊断时间和阶段分析整体存活率.
- 对时间生存关联的基准临床试验进行了审查.
主要成果:
- iCCA发病率从每10万人中从0.49上升至1.38 (APC6.94%),各子组呈上升趋势.
- 平均整体存活时间 (mOS) 从2000年的5.28个月提高到2013年的9.3个月,随后稳定下来.
- 2010年后,基于十年的mOS增加到9.06个月;特定阶段的mOS有所不同 (例如,局部阶段的mOS为24.3个月).
结论:
- iCCA发病率在人口统计学上显示出一致的增加.
- 2010年后观察到的生存率改善已经停滞不前,这表明需要新的治疗策略.
- 进一步分析最近的临床试验对生存的影响是有必要的.
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