GH受体多态性指导二线疗法,以预防骨脆弱性:试点研究的初步结果
Sabrina Chiloiro1,2, Flavia Costanza1,2, Antonella Giampietro1,2
1Dipartimento di Medicina Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.
Frontiers in endocrinology
|September 16, 2024
概括
GH受体 (GHR) 异型预测在二线治疗中的壮病患者的脊椎骨折 (VF). 了解GHR多态性可以指导个性化治疗选择,以减少骨折风险.
科学领域:
- 内分泌学 在内分泌学.
- 遗传学 遗传学 是一个
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 巨症与脊椎骨折 (VFs) 的增加有关.
- 关于生长激素受体 (GHR) 异型在预测VF中的作用的数据有限.
- 这项研究调查了GHR多态性在偶发性VFs (i-VFs) 中的GHR多态性的作用,在接受二线治疗的壮症患者中.
研究的目的:
- 探索GHR多态化在i-VFs发生中的预后作用.
- 评估GHR异型体对接受特定二线治疗的壮病患者的风险的影响.
主要方法:
- 一项追溯观察性研究,对45名壮病患者进行了追溯观察,这些患者对第一代体静止素受体配体 (fg-SRLs) 没有反应.
- 患者接受了Pegvisomant (GHR抗剂) 加上fg-SRL或长效释放 (LAR) 的帕西雷奥提德.
- 确定了GHR异型 (fl-GHR和d3-GHR),并分析了i-VF的发生.
主要成果:
- 在fg-SRLs + Pegvisomant组中,i-VFs仅发生在fl-GHR载体中 (p=0.039).
- 在Pasireotide LAR组中,i-VFs仅发生在d3-GHR载体中 (p=0.018).
- fl-GHR携带者在fg-SRL+Peg-V (OR:1.6) 中增加了i-VF风险,在Pasireotide LAR (OR:0.26) 中降低了风险.
结论:
- GHR异型体在接受二线治疗的壮病患者中显示出i-VFs的预测作用.
- 识别GHR多态性可以帮助选择个性化的二线治疗.
- 这种方法可能会改善个人化医学中的治疗策略.
相关概念视频
Transducer Mechanism: Enzyme-Linked Receptors
2.4K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Major types that are helpful drug targets include:
2.4K
GPCRs Regulate Adenylyl Cylase Activity
5.3K
Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...
5.3K
Transducer Mechanism: G Protein–Coupled Receptors
1.9K
G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical,...
GPCRs are also called heptahelical,...
1.9K
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
398
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
398
G Protein-coupled Receptors
11.5K
G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
11.5K
Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers
147
Receptor tyrosine kinase inhibitors (TKIs) and calcium channel blockers (CCBs) are two critical categories of drugs employed in the treatment of pulmonary artery hypertension (PAH). PAH is a disease that causes high blood pressure in the pulmonary arteries, resulting in chest pain, fatigue, and shortness of breath.
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
147


