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与没有生物增强的修复相比,生物增强在关节镜修复旋转形修复方面表现出类似的结果和失败率
Robert T Tisherman1, Matthew N Como2, Osatohamwen I Okundaye2
1Duke University, Durham, NC, USA.
JSES international
|September 16, 2024
概括
使用自身条件化血 (ACP) 或原蛋白贴片进行生物增强并没有改善修复旋转手套修复的愈合或结果. 这项研究发现,增强修复和非增强修复修复之间的失败率或患者报告结果没有显著差异.
科学领域:
- 整形外科手术 整形外科手术
- 再生医学是一种再生医学.
- 生物材料是一种生物材料.
背景情况:
- 修复旋转手套修复 (RCRs) 的愈合率低于初级修复.
- 关于修订RCRs的生物增量存在有限的证据.
- 自主调节血 (ACP) 和生物诱导贴片在初级修复方面表现有前途.
研究的目的:
- 评估ACP和原牛补丁增强的结果,以修改关节镜RCR.
- 为了确定生物增强是否改善患者报告的结果 (PROs) 和修复RCR中的愈合率.
- 为了比较修订RCR结果与没有生物增量.
主要方法:
- 对38名接受关节镜复查RCR (2010-2021) 的患者进行了回顾性病例控制研究.
- 生物增强队列接受了ACP和/或牛原蛋白补丁.
- 收集的PRO包括ASES,VAS,Brophy和PROMIS分数;失败定义为ASES分数<60或再次出现.
主要成果:
- 生物增强 (31.6%) 和没有生物增强 (42.1%) 组之间的失败率没有显著差异 (P=.74).
- 在ASES,Brophy,PROMIS心理或PROMIS物理分数中没有显著的差异.
- 平均随访时间为3.5年,队列之间的随访时间没有差异.
结论:
- 用ACP或牛原蛋白补丁进行生物增量并没有在RCR修订中显示出改善的失败率或PRO.
- 目前的生物增强策略可能无法提高修复旋转片修复的结果.
- 需要进一步的研究,以确定修订RCR的有效辅助.
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