癌症中免疫检查点抑制剂的肝胆道并发症
Donna Zhuang1,2, David Zhang1,2, Stephen Riordan1,2
1Gastrointestinal and Liver Unit, Prince of Wales Hospital, Randwick, New South Wales 2031, Australia.
Exploration of targeted anti-tumor therapy
|September 16, 2024
概括
免疫检查点抑制剂 (ICI) 可以改善癌症存活率,但可能导致肝损伤. 本综述探讨了ICI相关的肝胆毒性,重点是诊断和管理策略.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 免疫检查点抑制剂 (ICI) 已经彻底改变了癌症治疗,在改善各种恶性瘤患者存活率方面表现出显著的有效性.
- 已知ICI对多个器官系统的不良影响,对其现实世界的短期和长期临床影响越来越感兴趣.
- 与ICI相关的肝胆毒性存在诊断挑战,通常模仿异常肝功能测试的其他原因.
研究的目的:
- 为提供与免疫检查点抑制剂相关的肝胆道并发症的全面和当前审查.
- 阐明ICI诱导的肝损伤的发病,诊断方法和管理策略.
主要方法:
- 对研究免疫检查点抑制剂及其肝胆效应的研究进行系统性文献综述.
- 对ICI相关肝脏毒性的临床数据和病例报告的分析.
- 综合当前关于这些不良事件的机制,诊断和治疗的理解.
主要成果:
- 免疫检查点抑制剂与一系列肝胆毒性有关.
- 将ICI诱导的肝损伤与其他肝病区分开来,需要仔细的临床评估和诊断工作.
- 管理策略涉及及及时识别,适当的干预,有时停止ICI治疗.
结论:
- 了解ICI相关的肝胆道并发症的细微差别对于有效的患者管理至关重要.
- 本综述为临床实践中这些具有挑战性的毒性的诊断和管理提供了最新的视角.
- 需要进一步的研究来完善诊断标准,并优化ICI诱导的肝损伤的治疗方法.
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