佩林多普利尔降低了暴露于SARS-CoV-2 S1尖端蛋白的人类脂肪细胞中的血管氨酸转化酶2 (ACE2) 表达
Primasitha M Harsoyo1,2, Meity Ardiana1,2, Hanestya O Hermawan1,2
1Department of Cardiology and Vascular Medicine, Faculty of Medical, Universitas Airlangga, Surabaya, Indonesia.
Narra J
|September 16, 2024
概括
佩林多普里尔是一种血管激素转化酶2 (ACE2) 抑制剂,在暴露于SARS-CoV-2尖端蛋白的脂肪细胞中显著降低了ACE2表达和IL-6水平. 这表明在治疗病毒感染方面具有潜在的治疗作用.
科学领域:
- 内分泌学 在内分泌学.
- 病毒学 病毒学
- 药理学 药理学是指药理学的学科.
背景情况:
- 肥胖与脂肪组织中 angiotensin转化酶2 (ACE2) 表达的增加有关,可能促进像COVID-19这样的病毒感染.
- ACE 抑制剂的作用,如二,在调节 ACE2 表达和其对病毒病原性的影响仍然不清楚.
研究的目的:
- 为了研究二对ACE2表达和暴露于SARS-CoV-2 S1尖端蛋白的脂肪细胞中促炎性细胞因子水平的影响.
主要方法:
- 来自肥胖男性捐赠者的脂肪组织被酶分离并暴露在SARS-CoV-2 S1尖端蛋白中.
- 使用ELISA量化ACE2表达,使用人类重组ACE2 (hrsACE2) 和大兴作为治疗方法.
- 此外,还评估了白蛋白-6 (IL-6) 的水平.
主要成果:
- 暴露于SARS-CoV-2尖蛋白显著增加了脂肪细胞中的ACE2表达.
- 与阳性对照组 (80.31 μg/mL) 相比,佩林多普里尔的使用显著降低了ACE2表达 (43.37 μg/mL) (p<0.001).
- 佩林多普里尔治疗也显著降低了IL-6水平 (p<0.001).
结论:
- 佩林多普利尔有效地减少了SARS-CoV-2 S1尖端蛋白刺激的脂肪细胞中的ACE2表达.
- 在这种情况下,大兴通过降低IL-6水平来表现出抗炎作用.
- 这些发现表明,二在缓解与高ACE2表达相关的病毒感染方面具有潜在的治疗益处.
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