更严重的并发病,晚年和不完全接种疫苗会增加COVID-19死亡率的风险
Lukita Pradhevi1,2, Gatot Soegiarto1,2, Laksmi Wulandari3,4
1Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
严重的并发病,老年和不完全的COVID-19疫苗接种显著增加了死亡风险. 相反,接种疫苗可以降低2019年新冠肺炎疾病 (COVID-19) 的死亡风险.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 伴随性疾病是已确定的COVID-19死亡率的风险因素.
- 很少有研究研究了伴随性疾病的严重程度或阶段对COVID-19结果的影响.
研究的目的:
- 确定伴随性疾病严重程度,年龄和COVID-19疫苗接种状态与COVID-19死亡率之间的关联.
- 为了确定有助于冠状病毒疾病2019年死亡率的特定风险因素.
主要方法:
- 一项涉及1046名COVID-19患者 (450人没有生存,596人幸存) 的病例控制研究,从2021年7月到2022年12月进行.
- 纳入标准:成年患者通过RT-PCR确认了COVID-19.
- 使用多变量分析来评估各种因素与死亡率的关联.
主要成果:
- 高龄,男性性别,严重的COVID-19,肺炎,控制不良的糖尿病 (DM),严重的肥胖,高血压阶段2-3,CKD阶段3-5和慢性肺部疾病与COVID-19死亡率的增加有关.
- 糖尿病,慢性病和高血压是最常见的并发症.
- 接种COVID-19疫苗与死亡风险降低有关.
结论:
- 更严重的并发病,晚年和不完全接种疫苗是COVID-19死亡率的重要风险因素.
- 糖尿病,高血压和慢性病等疾病的严重程度在COVID-19结果中起着至关重要的作用.
- 接种COVID-19疫苗证明了对死亡率的保护作用.
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