在人类中,胰岛-状体结构连接在很大程度上偏向于像状体或像矩阵的状体隔间
Adrian T Funk1, Asim Ao Hassan2, Jeff L Waugh1,3
1Division of Pediatric Neurology, Department of Pediatrics, University of Texas Southwestern, Dallas, TX, USA.
Neuroscience insights
|September 16, 2024
概括
这项研究在健康成年人中绘制了岛屿子区域和条纹区 (条纹体和矩阵) 之间的大脑连接. 发现揭示了不同的连接模式,这表明了岛内功能专业化的基础.
科学领域:
- 神经科学是一个神经科学.
- 人类大脑解剖学 人类大脑解剖学
- 在Connectomics上,我们提供了连接.
背景情况:
- 胰岛在感觉,运动,边缘和执行功能中发挥着关键作用,其功能障碍与神经精神疾病有关.
- 岛状状突出是众多的,针对不同的状区:状体和矩阵,它们在起源,连接性和功能上有所不同.
- 之前对特定区间的岛状状结构连接的绘制是有限的.
研究的目的:
- 在100名健康成年人中,绘制和量化19个岛屿子区域和条状体和矩阵区间之间的结构连接.
- 为了确定来自不同岛屿次区域的分区特定预测偏差.
- 调查岛内功能专业化的解剖基础.
主要方法:
- 扩散通道图被用来分析100名健康成年人的结构连接性.
- 在19个定义的岛屿子区域和条形状的状体样和矩阵样voxels之间绘制了连接.
- 精简密度和分布被量化以确定投影偏差.
主要成果:
- 针对体和矩阵区的岛状状流线起源于不同的岛区,并遵循不同的路径.
- 在19个岛屿子区域中,16个显示显著偏向于立体体 (7个子区域) 或矩阵 (9个子区域) 分区.
- 偏向状体的捆绑体表现出更高的流线密度,特别是来自rostroventral岛屿子区域.
- 连接偏差在两个大脑半球都是一致的.
结论:
- 这项研究确定了特定的解剖基质,用于基于分离的胰岛-状连接到状区间的胰岛内功能专业化.
- 这些发现提供了一个详细的地图的岛屿 - 条形结构连接,突出区块特定的预测.
- 在结构连接中发现的偏差与使用其他方法的先前发现一致,加强了它们的意义.
更多相关视频
08:36Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
Published on: March 21, 2019
7.2K
09:55Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex
Published on: September 5, 2018
8.3K
相关概念视频
Cerebrum: Anatomical Overview II
1.6K
Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...
1.6K
Golgi Matrix Proteins
2.0K
Golgi matrix proteins are a group of highly dynamic proteins that maintain the stacked structure of Golgi. These proteins adapt to rapid morphological changes of the Golgi during the cell cycle. During cell division, mild proteolysis removes these connections resulting in Golgi unstacking. In The daughter cells, these proteins help reassemble the unstacked Golgi.
One of the first identified Golgi matrix proteins was GM130, a rod-like protein located in the cis-Golgi. Subsequently, many Golgi...
One of the first identified Golgi matrix proteins was GM130, a rod-like protein located in the cis-Golgi. Subsequently, many Golgi...
2.0K
