解码口腔致癌和瘤进展在整个香烟烟雾暴露:一个系统性审查
Jiao Li1,2, Nurhayu Ab Rahman3, Suharni Mohamad4
1Pathology, School of Dental Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian, MYS.
Cureus
|September 16, 2024
概括
全香烟烟雾通过改变人类口腔细胞中的关键分子通路来推动口腔癌的发展和进展. 本综述详细介绍了诸如血红素通路异常和RAGE信号激活等机制.
科学领域:
- 分子生物学分子生物学
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
背景情况:
- 口腔状细胞癌 (OSCC) 是一个重要的全球健康问题.
- 吸烟是OSCC发展的主要危险因素.
- 了解整个香烟烟雾 (WCS) 的分子影响对于向治疗至关重要.
研究的目的:
- 系统地审查和突出WCS在口腔癌发生和进展中的分子机制.
- 综合来自对暴露于WCS.的人口细胞的原始研究的证据.
主要方法:
- 在Web of Science,Scopus和PubMed的系统文献搜索 (2024年5月至6月).
- 根据PRISMA (2020) 准则进行选和数据提取.
- 使用SYRCLE工具对14项纳入研究进行偏差评估.
主要成果:
- 通常使用的细胞系:人类口腔粘膜上皮细胞和OSCC细胞.
- 暴露方法包括WCS,烟雾提取物或凝结物.
- 确定了关键的分子机制:血质通路异常,miRNA-145调制,NOD1,BiP的改变表达,MMP-2,MMP-9,甲素,异常的TSPO结合,RIP2介导的NF-κB激活,MZF1介导的VEGF结合和RAGE信号激活.
结论:
- 在人类口腔细胞中,WCS显著影响口腔癌发生和OSCC在分子和细胞水平上的进展.
- 本综述提供了一个全面的了解WCS影响超出特定致癌物.
- 这些发现强调了在口腔癌预防和治疗策略中解决WCS暴露的重要性.
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