在有或没有2型糖尿病患者中,手臂-脚脉冲波速和下腿周长比率之间的差异
Tomoki Furuya1,2,3, Shinji Kitahama4, Daichi Yamashiro5
1Research Team for Social Participation and Healthy Aging, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Itabashi, JPN.
Cureus
|September 16, 2024
概括
腿周率可以评估2型糖尿病 (T2DM) 患者的动脉硬性,可能取代手足脚脉冲波速度 (ba-PWV) 测量. 这一发现是T2DM个体特有的,突出了腿部测量和血管健康之间的独特关系.
科学领域:
- 心血管健康 心血管健康
- 代谢障碍 代谢障碍 代谢障碍
- 生物医学工程 生物医学工程
背景情况:
- 在2型糖尿病 (T2DM) 中血管内皮功能障碍有助于动脉样硬化和微血管并发症.
- 动脉硬是心血管风险的关键指标,通常通过手腕关节脉冲波速率 (ba-PWV) 来评估.
研究的目的:
- 研究T2DM患者与非糖尿病患者相比,腿周长和动脉硬之间的关系.
- 确定腿周长测量是否可以作为T2DM动脉硬性的替代标记.
主要方法:
- 结合了两项研究的数据,形成T2DM和非T2DM队列.
- 收集的变量包括人口统计,血压,ba-PWV,脚-手臂指数和腿周长测量.
- 用ba-PWV作为依赖变量进行了多重回归分析,检查了腿周长比和T2DM状态之间的相互作用.
主要成果:
- 在下腿周长比和T2DM状态之间发现了关于ba-PWV的显著相互作用 (p < 0.01).
- 在T2DM组中,下腿周长比率下降与ba-PWV增加显著相关 (p <0.05).
- 在非T2DM组中没有观察到下腿周长比和ba-PWV之间的显著关系 (p = 0.69).
结论:
- 腿周率与T2DM患者的动脉硬性 (ba-PWV) 特别相关.
- 腿周长比率可以作为ba-PWV的实用,非侵入性的替代方案,用于评估T2DM中的动脉硬度.
- 这一发现为监测2型糖尿病患者心血管风险提供了一种新方法.
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