通过纳米级金属有机框架恢复皮肤神经相互作用,用于糖尿病的愈合
Xiuru Ji1, Jingwei Zhou2, Zengding Zhou3
1Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197, Ruijin 2nd Rd, Shanghai, 200025, PR China.
Bioactive materials
|September 16, 2024
概括
糖尿病通过阻断皮肤与神经的相互作用来阻碍愈合. 一种新的纳米级疗法,NGF/CU,清除反应性氧物种 (ROS) 并有助于神经恢复,有效地促进糖尿病的愈合.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 纳米技术 纳米技术
背景情况:
- 糖尿病 (DUs) 由于神经病变和活性氧物种 (ROS) 而表现出受损的皮肤神经相互作用.
- 这种受损的相互作用显著阻碍了糖尿病患者的自然伤口愈合过程.
- 现有的治疗方法往往无法解决DU的潜在神经炎症环境.
研究的目的:
- 开发和评估一种带有神经生长因子 (NGF/Ce-UiO-66,NGF/CU) 的新型纳米金属有机框架,用于治疗糖尿病.
- 研究NGF/CU在清除ROS和促进皮肤神经恢复方面的双重治疗作用.
- 阐明NGF/CU在加速DU愈合中的有效性背后的分子机制.
主要方法:
- 合成Ce-UiO-66 (CU) 作为抗氧化剂和NGF加载,以创建NGF/CU纳米粒子.
- 在体外和体内对NGF/CU在促进糖尿病愈合方面的疗效进行了评估.
- RNA测序分析以确定NGF/CU治疗调节的分子通路.
主要成果:
- NGF/CU有效地清除了ROS和减少了炎症,表明了对DU的显著治疗潜力.
- 在体外和体内研究都证实了NGF/CU治疗的糖尿病的加速愈合.
- NGF/CU治疗被证明可以抑制NF-κB信号通路并恢复皮肤的神经内分泌系统.
结论:
- 开发的NGF/CU纳米系统为增强糖尿病愈合提供了一个有前途的治疗策略.
- 这种方法有效地解决了 DU 中氧化应激和神经损伤的双重挑战.
- 通过NGF/CU的神经调节为治疗糖尿病和潜在的其他器官损伤提供了新的视角.
相关概念视频
01:31Diabetic Foot Ulcer
33
Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory...
33
01:22Diabetic Neuropathy
59
DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
59