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由icotinib诱导的急性泛化脱血性 pustulosis:一个病例报告和文献综述

Wei Yang¹, Jiayu Zhao¹, Jun Niu¹

¹Department of Dermatology, General Hospital of Northern Theater Command, Shenyang, China.

Frontiers in pharmacology

|September 16, 2024

概括

急性全身外血性 pustulosis (AGEP) 是一种罕见的药物反应. 这个案例突出了一个患者在治疗了icotinib后被诊断出AGEP,强调了迅速的识别和治疗.

科学领域:

皮肤病学皮肤病学
药理学药理学是指药理学的学科.
内部医学内部医学

背景情况:

急性全身脱血性 pustulosis (AGEP) 是一个罕见但严重的药物不良反应.
它的特点是发烧和广泛的小无菌在红血性皮肤上,通常在药物暴露后1-4天出现.
发病率较低,估计为每百万人中3-5人,死亡率约为5%.

研究的目的:

报告一名69岁的女性在接受伊科替尼治疗后出现AGEP病例.
审查关于AGEP的文献,将此案与之前报告的案例进行比较.
强调及时诊断和药物诱导的AGEP管理的重要性.

主要方法:

一个69岁的女性患有疹和发烧的临床病例呈现.
基于临床表现和药物史的诊断评估.
使用PubMed识别和比较AGEP的类似病例的文献评论.

主要成果:

患者在开始服用icotinib的四天后出现了扩散的红血性,性皮疹和发烧 (38.3°C).
根据临床发现和与药物的时间关系,AGEP的诊断得到了确认.
文献审查为这种罕见疾病的表现和管理提供了背景.

结论:

伊科蒂尼布可能是急性泛性脱血性 pustulosis 的潜在触发因素.
迅速识别和撤销违规药物对于管理AGEP至关重要.
这一案例强调了在对急性发烧性喷发的差异诊断中考虑药物反应的重要性.

关键词:

急性通用脱血性 pustulosis 的发生.药物不良反应药物不良反应伊科丁尼布的使用方法非小细胞肺癌的肺癌.氨酸激酶抑制剂氨酸激酶抑制剂

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