口服益生菌可以减轻马的运动后炎症
Robert D Jacobs1, Daniel Grum1, Benjamin Trible1
1Land O Lakes, Purina Animal Nutrition, Gray Summit, MO 63039, USA.
Translational animal science
|September 16, 2024
概括
细菌凝血素GBI-30,6086补充剂减少了马的运动引起的炎症. 这种益生菌可以通过调节炎症途径来支持马的健康和表现.
科学领域:
- 马的营养和运动生理学
- 微生物组和免疫学
背景情况:
- 益生菌在马的饮食中广泛用于健康益处,但科学证据证明它们在马的有效性有限.
- 来自Bacillus属的细菌在调节新陈代谢,免疫和炎症途径方面表现出潜力.
研究的目的:
- 评估精选的Bacillus益生菌在改变马匹对运动的炎症反应中的有效性.
- 为了比较Bacillus coagulans GBI-30,6086,Bacillus subtilis-1,Bacillus subtilis-2和Bacillus amyloliquefaciens对运动后炎症标志物的影响.
主要方法:
- 一个随机交叉试验,涉及18匹马,每匹马接受6次治疗,分为3周的阶段.
- 治疗包括一个负对照,一个正对照 (flunixin meglumine) 和四种Bacillus益生菌 (80亿CFU/d).
- 马匹进行了标准化的2小时运动测试,在运动前和运动后采集血液样本,以分析SAA,IL-6和PGE2.
主要成果:
- 运动在运动后显著增加了血清粉样蛋白A (SAA),干白素-6 (IL-6) 和前列腺素E2 (PGE2) 度.
- 与其他所有组相比,用Bacillus coagulans GBI-30,6086补充的马的SAA,IL-6和PGE2产量显著减少 (P < 0.001).
- 阳性对照组成功改善了运动后的炎症反应.
结论:
- 凝血杆菌GBI-30,6086在减轻马匹运动引起的炎症方面表现出显著的潜力.
- 这种益生菌可能是马类饮食的宝贵补充,以支持运动和其他诱导炎症的挑战的恢复.
- 需要进一步的研究来阐明这些观察到的抗炎作用背后的具体机制.
相关概念视频
01:20Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents
375
The gastric mucosa produces prostaglandins E2 (PGE2) and prostacyclin (PGI2), crucial in maintaining gastric health. They exert cytoprotective effects, including increasing bicarbonate secretion, releasing protective mucin, reducing gastric acid output, and preventing harmful vasoconstriction. These effects are mediated through various receptors, such as EP1, EP2, EP3, and EP4.
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
375
01:20Exercise and Cardiovascular Response
746
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
746
01:26Peptic Ulcer Disease IV: Management
75
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
75