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低眼 perfusion 压力值在休息时和抵抗运动期间在青光眼患者的后代

Diana de Medeiros Andrade¹, Jordane Benedito Vargas Oliveira², Marta Halfeld Ferrari Alves Lacordia²

¹Cardiovascular Research Unit and Exercise Physiology, Federal University of Juiz de Fora, Minas Gerais, Brazil.

Journal of current ophthalmology

|September 16, 2024

概括

与没有 (FH-) 的人相比,患有青光眼家族病史 (FH+) 的个体具有较低的基线眼 perfusion 压力 (OPP) 和在运动期间 OPP 的百分比增加. 这表明FH+个体的血液动力学反应发生变化.

科学领域:

眼科医生眼科眼科
心血管生理学心血管生理学
玻璃眼研究研究玻璃眼研究

背景情况:

玻璃眼是全球不可逆转的失明的主要原因.
眼球输液压 (OPP) 是青光眼病发病的一个关键因素.
对于OPP对生理压力的反应,如运动,还不完全理解,特别是在有格劳科马家族病史的人群中.

研究的目的:

在具有 (FH+) 和没有 (FH-) 绿眼家族病史的个体中,研究和比较在同位体握手运动期间的眼 perfusion 压力 (OPP) 响应.
为了确定青光眼家族病史是否影响基线OPP及其在体力运动期间的动态变化.

主要方法:

34名受试者被分为两个组:FH+ (n=17) 和FH- (n=17).
参与者进行了3分钟的休息,3分钟的同位体握手练习 (30%的最大自愿收缩) 和3分钟的恢复.
血压和眼内压在休息时,运动时和恢复时被测量,以计算平均OPP (mOPP).

主要成果:

与FH-组相比,FH+组的基线mOPP在两只眼睛中显著较低 (P < 0.001).
两组在运动期间都显示出mOPP的显著增加 (P < 0.001),观察到类似的绝对增加.
与FH-组相比,FH+组在运动期间的mOPP的百分比增加明显更大 (右眼:34.1%±15.9%与22.1%±13.2%,P=0.025).

结论:

平均OPP在体育炼期间增加,无论是有或没有格劳科马家族史的个人.
患有青光眼家族史的人在基线和运动期间表现出较低的绝对mOPP值.
在FH+组显示了可能更高的mOPP的相对增加,以应对运动,表明改变了血液动力学调节.

关键词:

运动运动运动.眼光障碍眼光障碍眼光障碍眼光障碍遗传性遗传性遗传性眼睛生理现象眼睛生理现象

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