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Updated: Jun 13, 2025

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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
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克洛托与脏和心血管结果之间的关联:全面的系统性审查和元分析
Mehmet Kanbay1, Crischentian Brinza2,3, Lasin Ozbek4
1Department of Medicine, Division of Nephrology, Koç University School of Medicine, Istanbul, Turkey.
Clinical kidney journal
|September 16, 2024
概括
慢性病 (CKD) 患者中较低的klotho水平预测了较高的死亡率和不良事件. 这一发现强调了klotho作为病进展和患者结果的关键预后标志物.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生物标志物 生物标志物
- 慢性疾病管理 慢性疾病管理
背景情况:
- 慢性病 (CKD) 和末期病 (ESKD) 在全球面临重大健康挑战.
- 这些情况与逐渐的功能障碍,心血管疾病和死亡率增加有关.
- 调查预后标志物对于管理CKD和ESKD患者至关重要.
研究的目的:
- 探索血中klotho水平与CKD和ESKD患者的预后结果之间的关联.
- 评估klotho在预测全因死亡率,心血管事件和脏不良事件中的作用.
- 评估克洛托水平与脏替代疗法的需要之间的关系.
主要方法:
- 使用主要的电子数据库 (PubMed,MEDLINE,科学网等) 进行了系统的文献审查. ) 的情况.
- 该审查遵循了系统审查和元分析 (PRISMA) 的首选报告项目指南.
- 这项分析包括了14项研究.
主要成果:
- 较低的克洛托水平与所有原因死亡率 (OR 1.81) 和心血管死亡率 (OR 2.11) 的增加显著相关.
- 低克洛托的患者患脏不良事件的风险更高 (OR 2.36) 和进展到ESKD或脏替代疗法 (OR 2.30).
- 虽然复合心血管事件没有显著差异,但异质性很高.
结论:
- 血清中克洛托水平降低是CKD患者不良结果的重要预测因素.
- 低克洛托与增加死亡风险和进展到末期病的风险有关.
- 克洛托可以作为一个有价值的预后生物标志物在治疗病的管理.
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