在急性缺血性中风患者中,中性粒细胞与淋巴细胞的比率和五年死亡率
Yisi Shan1, Rong Zhang1, Juan Lu1
1Department of Neurology, The Affiliated Zhangjiagang TCM Hospital of Yangzhou University, Suzhou, 215600, China.
Heliyon
|September 16, 2024
概括
在急性缺血性中风 (AIS) 患者中,中性粒细胞与淋巴细胞比率 (NLR) 的升高与五年死亡率的增加有关. 较高的NLR水平显著预测AIS幸存者的全因和血管死亡率.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 血液学 血液学 血液学
背景情况:
- 中性粒细胞与淋巴细胞的比率 (NLR) 是急性缺血性中风 (AIS) 中已知的短期死亡率预测因素.
- 在AIS后的NLR和长期死亡率之间的关联仍然不完全理解.
- 这项研究旨在阐明入院NLR和AIS患者五年死亡率之间的关系.
研究的目的:
- 研究急性缺血性中风 (AIS) 患者入院中性粒细胞与淋巴细胞比率 (NLR) 和五年全因死亡率之间的关联.
- 检查入院NLR和AIS患者五年血管死亡率之间的相关性.
- 在AIS中确定长期死亡率的独立预测因素.
主要方法:
- 分析了2012年4月至2016年1月期间入院的416名AIS患者.
- 招生NLR被分类为四分位数进行比较分析.
- 使用卡普兰-梅尔曲线,考克斯回归和ROC曲线分析评估的五年死亡率.
主要成果:
- 在五年内,32.2%的患者经历了全因死亡率和27.4%的血管死亡率.
- 升高的NLR四分位数表明,对所有原因和血管死亡的风险显著增加,取决于剂量.
- 多变量分析确定了NLR,中风史和NIHSS得分作为五年全因和血管死亡率的独立预测因素.
结论:
- 入院中性粒细胞与淋巴细胞比率 (NLR) 是急性缺血性中风 (AIS) 患者五年全因和血管死亡率的重要独立预测指标.
- 较高的NLR水平与AIS后长期死亡风险大幅增加有关.
- 在AIS幸存者中,NLR可以作为一个有价值的预后生物标志物来分层长期风险.
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