瘤大小与小肠腺癌患者的预后之间的关联 - 一项基于SEER的研究
Jialin Zhou1,2, Cong Wang1, Tingcong Lv1
1Department of General Surgery, The Third People's Hospital of Dalian, Dalian Medical University, Dalian, China.
Heliyon
|September 16, 2024
概括
瘤大小是小肠腺癌 (SBA) 预后不佳的独立预测因素. 较大的SBA瘤与较差的整体存活率 (OS) 和癌症特异性存活率 (CSS) 相相关,导致修改T阶段以改善分期.
科学领域:
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
- 癌症研究 癌症研究
背景情况:
- 瘤大小在小肠腺癌 (SBA) 的预后意义仍然不完全理解.
- 利用监测,流行病学和最终结果 (SEER) 数据库来调查SBA瘤大小及其对患者结果的影响.
研究的目的:
- 评估小肠腺癌瘤瘤大小的预后价值.
- 评估瘤大小与生存结果 (总生存率和癌症特异性生存率) 之间的关联.
主要方法:
- 从SEER数据库中对术后SBA患者的分析.
- 考克斯的比例危险回归和受限制的立方线,以建模瘤大小和预后.
- 斯皮尔曼相关性用于评估瘤大小和T阶段之间的关系.
- 卡普兰-梅尔曲线用于生存分析.
主要成果:
- 定量分析瘤大小,独立预测较差的整体存活率 (HR=1.008,P=0.04) 和癌症特异性存活率 (HR=1.021,P=0.03).
- 瘤大小与瘤<3-4厘米的危险比率之间存在线性关系.
- 与AJCCT阶段相比,修改的T阶段 (mT) 结合瘤大小和入侵深度显示出更好的预后分层.
结论:
- 瘤大小是小肠腺癌中不良结果的重要独立预测因素.
- 一个新的,修改的T阶段系统整合了瘤大小和入侵深度,为SBA提供了增强的预后准确性.
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