2型糖尿病对膜擦拭器上皮质病变和眼睛表面参数的影响
Meiting Huang1, Xiaoming Yan1, Yuan Gao1
1Peking University First Hospital, Xicheng District, Beijing, China.
Heliyon
|September 16, 2024
概括
眼膜擦拭器表皮病 (LWE) 随着糖尿病的持续时间而恶化,可以帮助糖尿病患者早期诊断干眼病 (DED),可能会先于其他指标,如裂时间.
科学领域:
- 眼科医生 眼科 眼科
- 糖尿病学 糖尿病学
- 干眼疾病研究 干眼疾病研究
背景情况:
- 2型糖尿病 (DM) 与眼表面并发症有关.
- 在糖尿病患者中,早期诊断干眼病 (DED) 对于预防视力损伤至关重要.
研究的目的:
- 调查2型DM持续时间对盖片擦拭器上皮质病 (LWE) 的影响.
- 评估LWE作为糖尿病患者DED早期诊断标记物的实用性.
主要方法:
- 对137名具有OSDI分数≥13.0的受试者进行横截面研究.
- 分类为非DM,短期DM (<5年) 和中长期DM (≥5年) 组.
- 评估LWE,OSDI,脂质层厚度 (LLT),撕裂时间 (FTBUT) 和其他眼睛表面参数.
主要成果:
- 与非DM相比,中长期DM组的上方和总LWE得分较高.
- LWE严重程度与糖尿病持续时间相关;随着DM持续时间的延长,LLT降低,梅博米腺脱落 (MGd) 增加.
- 作为诊断指标的LWE产生了比FTBUT<5s更高的DED诊断率.
结论:
- 随着糖尿病的进展,LWE,LLT和MGd的状况恶化.
- LWE 变化可能会先于 FTBUT 变化,这表明 LWE 作为糖尿病患者早期 DED 诊断指标的潜力.
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