lysosomal transmembrane protein 5:对免疫细胞功能的影响和与免疫相关的缺陷的影响
Peng-Peng Sun1, Shi-Xia Liao2,3, Peng Sang1
1Department of Orthopedics Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Heliyon
|September 16, 2024
概括
溶解体相关蛋白5 (LAPTM5) 影响免疫细胞和瘤进展. 它的失调与免疫疾病,癌症和阿尔茨海默氏症有关,这表明它有可能成为治疗点.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 神经科学是一个神经科学.
背景情况:
- 溶解体相关蛋白5 (LAPTM5) 与免疫细胞受体相互作用,影响免疫反应.
- 失调的LAPTM5表达与免疫系统疾病和癌症发展有关.
- LAPTM5通过影响免疫细胞受体和细胞死亡途径,在瘤进展中发挥作用.
研究的目的:
- 审查LAPTM5在瘤和免疫相关疾病中的多方面的作用.
- 突出LAPTM5作为诊断,治疗和预后生物标志物的潜力.
- 总结当前关于LAPTM5参与瘤发生和免疫缺陷的见解.
主要方法:
- 关于LAPTM5在各种疾病中的功能研究的文献评论.
- 对LAPTM5对免疫细胞受体 (TCR/BCR) 和抗原呈现的影响的分析.
- 检查LAPTM5在非亡细胞死亡,细胞循环调节和神经疾病中的作用.
主要成果:
- 免疫细胞中LAPTM5的升高与抗原呈现受损和瘤免疫逃逸相关.
- 低调LAPTM5抑制了瘤细胞的死亡,促进了瘤发生.
- 异常的LAPTM5表达影响细胞循环的进展,并与阿尔茨海默病的严重程度有关.
结论:
- LAPTM5是瘤进展和免疫系统功能障碍的关键因素.
- 在细胞死亡,细胞循环和神经系统疾病中LAPTM5的参与需要进一步的研究.
- 作为一种潜在的生物标志物和各种疾病的治疗点,LAPTM5显示出前景.
相关概念视频
Lysosomal Hydrolases
3.8K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
3.8K
Lysosomes
16.9K
Lysosomes are membrane-enclosed spherical sacs derived from the Golgi apparatus. The most important function of the lysosome is degrading macromolecules and biological polymers that are released during membrane trafficking events such as the secretory, endocytic, autophagic, and phagocytic pathways. The degradation is carried out by several hydrolytic enzymes active in an acidic environment of the lysosomal lumen. These acid hydrolases are involved in cellular processes such as cell signaling,...
16.9K
The Significance of Membrane Transport
24.2K
The transport of solutes across the cell membrane is essential for metabolic processes, like maintaining cell size and volume, generating the action potential, exchanging nutrients and gases, etc. Membrane transport can be either passive or active. It can be simple diffusion, facilitated, or mediated transport aided by transport proteins such as transporters and channels.
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
24.2K
Delivery Pathways to the Lysosome
6.2K
Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
6.2K


