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在等离子体激活剂-抑制剂-1促进体中的4G/5G多态的影响COVID-19严重程度和内皮功能障碍

Tetiana Yatsenko^1,2, Ricardo Rios³, Tatiane Nogueira³

¹Department of Research Support Utilizing Bioresource Bank, Graduate School of Medicine, Juntendo University, Tokyo, Japan.

Frontiers in immunology

|September 16, 2024

概括

4G/5G等离子体激活剂抑制剂-1 (PAI-1) 多态的4G4G基因型与严重的COVID-19中抑制的纤维素分解有关. 5G5G基因型与炎症诱导的内皮功能障碍和纤维素过度激活有关.

科学领域:

遗传学是一个遗传学.
免疫学免疫学免疫学
心血管生物学心血管生物学

背景情况:

血原激活剂抑制剂-1 (PAI-1) 在严重的COVID-19中与血栓形成和内皮功能障碍有关.
PAI-1表达受到+43G>A和4G/5G促进基因多态化的影响.

研究的目的:

研究PAI-1基因多态化对COVID-19严重程度和内皮功能障碍的影响.
在COVID-19患者中阐明PAI-1基因型,纤维解和炎症之间的机制联系.

主要方法:

来自COVID-19患者的临床数据,血清和外周血液单核细胞 (PBMC) 的分析.
对于 +43 G>A 和 4G/5G PAI-1 促进物多形态的基因定型.
测量纤维解质因子,素-1β (IL-1β) 和NFκB激活.

主要成果:

4G/5G多态的4G4G基因型与高循环PAI-1,低IL-1β和等离子体水平相关,并抑制了纤维素分解.
在4G4G基因型的COVID-19患者的PBMC中,NFκB被上调.
5G5G基因型与炎症诱导的内皮功能障碍和纤维溶解系统过度活化有关.

结论:

在严重的COVID-19中,PAI-1多态显著影响纤维素分析活性和炎症反应.
4G4G基因型与纤维素分解受损相关,而5G5G基因型与内皮功能障碍和纤维素分解相关.
了解这些遗传倾向可能有助于风险分层和COVID-19的治疗策略.

关键词:

在 COVID-19 疫情中,PAI-1 4G/5G 促销器多态化 (rs1799889) 的研究结果一个PAI-1多态 +43G>A (rs6092) 的多态.它们是内皮细胞的内皮细胞.这是一种炎症炎症炎症炎症.塑; 介质蛋白-1-β; 介质蛋白-1-β;塑原激活剂抑制剂-1

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