动态对比增强的MRI测绘血管透性,用于评估乳腺癌的新辅助化疗反应,使用图像对图像条件生成对抗网络
Chad A Arledge1, Alan H Zhao2, Umit Topaloglu3,4
1Department of Biomedical Engineering, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
medRxiv : the preprint server for health sciences
|September 16, 2024
概括
这项研究引入了一种新的AI方法,使用条件生成对抗网络 (cGAN) 来从DCE-MRI扫描中快速创建详细的瘤血管透性图. 这种人工智能方法可以准确预测乳腺癌患者的治疗反应,显著加快分析速度.
科学领域:
- 医疗成像医学成像
- 人工智能在医学中的应用
- 在瘤学瘤学.
背景情况:
- 动态对比增强 (DCE) MRI对于使用药理动力学 (PK) 模型量化瘤微血管透性至关重要.
- 传统的PK建模是计算密集的,限制了其用于DCE-MRI分析的临床应用.
- 图像对图像条件生成对抗网络 (cGAN) 对复杂的图像翻译任务显示出前景.
研究的目的:
- 从DCE-MRI数据开发和验证一种基于cGAN的新型方法,用于从DCE-MRI数据快速生成PK血管透性参数图.
- 评估开发的cGAN模型在绘制血管透性的准确性和效率.
- 评估cGAN衍生的透性参数对预测乳腺癌患者新辅助化疗反应的有用性.
主要方法:
- 开发了一种新的图像对图像cGAN (DCE-to-PK cGAN),用于直接将DCE-MRI数据映射到PK血管透性参数图.
- 通过使用来自癌症成像档案 (TCIA) 的开源乳腺癌患者DCE-MRI数据来训练和验证cGAN模型.
- 分析了从cGAN生成的地图中获得的Ktrans的百分比变化,以预测治疗反应.
主要成果:
- DCE-to-PK cGAN成功生成了高质量的血管透性参数图,与地面真相相比较.
- 与传统的PK建模相比,cGAN方法实现了超过1000倍的计算速度.
- 通过分析Ktrans的百分比变化来实现新辅助化疗响应者的早期预测,这与之前的研究一致.
结论:
- 开发的DCE-to-PK cGAN提供了一种高效和准确的方法,用于从DCE-MRI生成血管透性图.
- 这种人工智能驱动的方法显著减少了分析时间,促进了临床翻译.
- 由cGAN衍生的Ktrans变化为早期预测乳腺癌治疗反应提供了可靠的生物标志物.
更多相关视频
06:24Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model
Published on: April 18, 2015
15.1K
10:25Author Spotlight: Integrating High-Resolution Intravital Imaging and MRI to Enhance Stereotactic Body Radiation Therapy Planning
Published on: April 12, 2024
1.3K
相关概念视频
Assessment of Diffusion and Perfusion
Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this principle...
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this principle...
Magnetic Resonance Imaging
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
Radiological Investigation II: MRI and Ventilation Perfusion Scan
Description
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...
Imaging Studies VII: Vascular Imaging
DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
