性别特定的骨肌肉基因表达对运动的反应揭示了小说 胰岛素敏感性的直接媒介 变化
S Ma1, M C Morris2, M J Hubal3
1Institute for Health Informatics (IHI), Academic Health Center, University of Minnesota, Minneapolis, MN 55455.
medRxiv : the preprint server for health sciences
|September 16, 2024
概括
运动通过男性和女性不同的分子通路改善胰岛素敏感性. 这些路径受到运动强度和数量的影响,突出了复制运动益处的潜在药物标.
科学领域:
- 运动生理学和分子生物学.
- 基因组学和系统生物学.
- 内分泌学和代谢健康.
背景情况:
- 运动对人类健康的影响涉及复杂的分子信号通路.
- 骨肌肉基因表达的变化是理解运动对全身胰岛素敏感性 (Si) 的影响的关键.
- 调查性别特异性,运动量和强度差异可以揭示药理干预的目标.
研究的目的:
- 探索与有氧运动改善全身胰岛素敏感性 (Si) 相关的分子信号通路.
- 为了分析骨肌肉基因表达的性别差异,以应对运动.
- 确定模仿运动健康益处的药物的潜在分子标.
主要方法:
- 在8个月的有氧训练后,对来自STRRIDE I和II试验的53名参与者的骨肌肉基因表达的分析.
- 使用静脉注射葡萄糖耐受性测试评估训练前和训练后的胰岛素敏感性 (Si).
- 应用一种新型基因发现协议,整合建模策略,从差异表达的转录中识别因果因素.
主要成果:
- 在女性中,转录因子目标主要受到运动量 (抑制性) 的影响;在男性中,运动强度 (激活性).
- 在两性中常见的激活转录因子包括ATF1,CEBPA,BACH2和STAT1.
- 确定的主要途径是雌激素和醇 (PKC) 信号传递,汇聚在表皮生长因子受体 (EGFR),调解运动诱导的Si改善.
结论:
- 通过有氧运动诱导的Si改善通过性别特异的信号通路进行介导,进一步根据运动强度和数量进行区分.
- 与Si改善相关的骨肌肉适应包括雌激素和PKC信号传递.
- EGFR和其他已识别的标代表了模仿运动益处的潜在骨肌特异性药物标.
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