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Updated: Jul 5, 2026

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status
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连接大脑中的粉样蛋白负担的基因组和蛋白质组签名

Raquel Puerta1,2, Itziar de Rojas1,3, Pablo García-González1,3

  • 1Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.

medRxiv : the preprint server for health sciences
|September 16, 2024
PubMed
概括

这项研究将粉样蛋白生物标记物的全基因组关联研究 (GWAS) 与蛋白质组数据相结合,以确定阿尔茨海默病 (AD) 的遗传因素. 研究人员发现了与粉样蛋白负担相关的APOE和GADL1位点,为AD的复杂遗传结构提供了洞察力.

关键词:
Aβ42 Aβ42 Aβ42 Aβ42 Aβ42 Aβ42 Aβ42 Aβ42 Aβ42在CSF的生物标志物中.在GWAS中,GWAS就是GWAS.皮特断层扫描 PET断层扫描蛋白质组是蛋白质组的组成部分.

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