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非向的代谢和肠道微生物群调节研究发酵棕对肥胖的研究

Kaliyan Barathikannan^1,2, Ramachandran Chelliah^1,3, Selvakumar Vijayalakshmi¹

¹Department of Food Science and Biotechnology, College of Agriculture and Life Sciences, Kangwon National University, Chuncheon 24341, Republic of Korea.

|September 16, 2024

概括

用Pediococcus acidilactici MNL5发酵的棕可以通过改善肠道健康和减少身体脂肪来预防肥胖. 这种功能性食物在代谢健康管理方面表现有前途.

科学领域:

微生物学微生物学
营养科学营养科学
代谢学代谢学代谢学

背景情况:

肥胖是心脏病,高血压和糖尿病的主要危险因素.
植物性益生菌发酵食品为预防肥胖提供了一个潜在的策略.
Pediococcus acidilactici MNL5是一种益生菌,具有潜在的健康益处.

研究的目的:

为了研究Pediococcus acidilactici MNL5增强发酵棕 (FBR) 对肥胖的影响.
分析FBR的代谢物概况,脂酶活性和抗氧化剂效率.
在高脂肪饮食诱导的肥胖小鼠模型中评估FBR的疗效.

主要方法:

使用UHPLC-Q-TOF-MS/MS.进行非目标代谢物分析.
生物化学测定,组织学分析,肠道微生物组测序和小鼠血清代谢学.
在中剂量 (250毫克/公斤) 的FBR给高脂肪饮食养的小鼠.

主要成果:

与原始棕大米相比,FBR表现出增强的抗氧化和脂酶抑制特性.
在肥胖小鼠中,FBR的使用显著降低了体重和脂肪含量.
FBR改善了肠道微生物群的多样性,减少了与肥胖相关的细菌,增加了有益细菌,与改善的脂质资料相关.

结论:

增强MNL5的Pediococcus acidilactici发酵棕显示了作为一种功能性食物的潜力,可以改善肥胖.
FBR积极调节肠道微生物群组成和与肥胖相关的代谢参数.
进一步研究FBR作为代谢障碍的治疗剂是有必要的.

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