PheW2P2V:一个全现象预测框架,使用电子健康记录加权患者表示
Jia Guo1, Krzysztof Kiryluk2, Shuang Wang1
1Department of Biostatistics, Columbia University, New York, NY 10032, United States.
JAMIA open
|September 16, 2024
概括
PheW2P2V是一个全现象预测框架,它使用加权的患者向量来根据电子健康记录 (EHR) 量身定制的临床结果预测. 与基线方法相比,这种方法在疾病表型预测方面提供了卓越的性能.
科学领域:
- 计算生物学是一种计算生物学.
- 生物医学信息学是生物医学信息学.
- 机器学习在医疗保健中的应用
背景情况:
- 电子健康记录 (EHR) 为预测建模提供了丰富的数据.
- 现有的方法经常为特定的临床结果创造单一用途的工具.
- 需要灵活的,全现象的预测框架.
研究的目的:
- 开发和评估PheW2P2V,一个全现象预测框架,使用加权的患者向量.
- 从EHR数据中为各种临床表型提供量身定制的预测.
- 提高医疗保健预测建模的效率和准确性.
主要方法:
- PheW2P2V使用Phecode映射来定义表型,减少数据冗余和错误分类.
- 用医疗记录的数值表示来创建患者载体,根据特定表型的相关性加权.
- 该框架采用医疗概念嵌入,并利用标记和未标记的数据.
主要成果:
- 在MIMIC-III数据库中,PheW2P2V在942个全现象预测中表现出卓越的性能.
- 中位数AUC-ROC为0.74,表现优于基线方法 (≤0.72).
- 中位数最大F1得分和AUC-PR也比基线方法有所改善.
结论:
- PheW2P2V提供了临床疾病表型的有效和准确的全现象预测.
- 该框架的灵活性和性能使其成为早期诊断和风险分层的宝贵工具.
- 建议进行进一步的研究,以探索嵌入在不同医疗保健数据集中的可转移性.
相关概念视频
Methods of Documentation VII: EMR
827
Electronic Medical Records (EMRs) primarily center around electronically documenting patients' health information within a single healthcare organization or practice. They contain essential clinical data related to a patient's medical history, diagnoses, medications, treatment plans, lab results, and other pertinent information relevant to the specific encounter or episode of care. EMRs are designed to streamline documentation and workflow processes within individual healthcare...
827
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models
64
Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
64
Issues And Trends In Healthcare Delivery System
5.6K
The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
5.6K
Model Approaches for Pharmacokinetic Data: Physiological Models
36
Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
36
Classification of Illness
7.4K
The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
7.4K
Patient-centered Care
2.0K
Patient-centered care involves delivering care beyond inpatient hospitalization. Reflective practice can enhance a patient-centered approach. Reflective practice is a process of reasoning that considers all aspects of the present situation, including practicalities, learning from personal practice, and consideration of patient needs. Patients appreciate care decisions made while considering their input. Involving the patient in their care provides the patient with a sense of contribution rather...
2.0K


