高压干预改善了长期高空暴露对认知控制能力的负面影响
Hong Ren1, Yun-Peng Zhu1, Rui Su1
1Plateau Key Laboratory of High Altitudes Brain Science and Environmental Acclimation, Tibet University, Lhasa, China.
Frontiers in physiology
|September 16, 2024
概括
高海拔暴露会损害新来者的认知控制能力 (CCC). 高压氧气 (HBO) 疗法有效地改善了CCC,为高海拔地区的认知衰退提供了潜在的干预措施.
科学领域:
- 高度医学 高度医学
- 认知神经科学 认知神经科学
- 生理学 生理学 生理学
背景情况:
- 高海拔环境呈现低氧,降低氧气局部压力,并影响移民的认知功能.
- 执行功能是一个关键的认知组成部分,由于其高代谢需求,对氧气水平很敏感.
- 认知控制能力 (CCC) 量化了执行职能,可以通过诸如多数职能任务 (MFT-M) 等任务进行测量.
研究的目的:
- 调查长期高空暴露对新来者的CCC的影响.
- 评估高压氧 (HBO) 干预措施在改善高海拔诱导的认知衰退方面的疗效.
主要方法:
- 研究1:使用MFT-M对高海拔新来者 (n=64) 和低海拔居民 (n=64) 的CCC进行比较.
- 研究2:在使用MFT-M干预前后对照组 (n=28) 与使用MFT-M干预前后对照组 (n=28) 进行评估,对15次HBO会话后高空新来者 (n=56) 的CCC变化进行评估.
主要成果:
- 与低海拔居民相比,高海拔新来者表现出明显较低的CCC (p=0.031).
- 与对照组 (p=0.972) 不同的是,HBO组的干预后CCC显著增加 (p=0.005),而HBO组的干预后CCC显著增加 (p=0.005).
- 干预后,HBO组的正确任务率明显高于对照组 (p=0.001).
结论:
- 长期高空暴露显然会损害新来者的认知控制能力.
- 高压氧干预在增强CCC方面被证明是有效的,这表明在高海拔地区对认知功能的可行治疗策略.
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