从肝硬化到失能症 (治愈或并发症的循环?)
Aanchal Bharti1, Isar Sharma1, Ritu Mahajan1
1School of Biotechnology, University of Jammu, Jammu, Jammu and Kashmir 180006 India.
Indian journal of microbiology
|September 16, 2024
概括
恢复肠道微生物组平衡 (eubiosis) 可能有助于逆转肝硬化中的肝损伤. 微生物组调制还显示出治疗酒精成和相关问题的前景,通过影响肠-肝-大脑轴.
科学领域:
- 胃肠病学和肝病学
- 微生物学 微生物学
- 神经科学是一个神经科学.
背景情况:
- 肠道微生物组不平衡的肠道失调与肝硬化密切相关,肝硬化是肝脏痕的特征.
- 肝硬化时肠道透性增加可以触发免疫反应,损害正常的身体功能并加剧肝损伤.
- 失生症可能会导致肝脏疾病的进展,可能导致肝功能衰竭和肝细胞癌.
研究的目的:
- 审查恢复肠道微生物组平衡 (eubiosis) 的潜力,以逆转肝硬化肝脏的功能衰退.
- 探索微生物组干预措施在控制酒精诱导肝硬化和相关的神经并发症中的作用.
主要方法:
- 文献综述侧重于肠道失调和肝硬化之间的关系.
- 分析研究研究益生菌,益生菌和抗生素对肠道微生物组合和肝功能的影响.
- 检查肠-肝-大脑轴及其通过微生物干预的调制的研究.
主要成果:
- 活生菌可以通过使微生物组能够有效地处理肝脏产品来恢复正常的肝功能.
- 包括益生菌和益生菌在内的微生物组校正策略为治疗慢性肝病提供了希望.
- 微生物干预显示出通过影响神经递质通路来调节酒精成和相关抑郁症的潜力.
结论:
- 恢复肠道微生物组平衡是肝硬化治疗的有希望的治疗策略.
- 基于微生物组的方法可以解决肠-肝-大脑轴,有利于肝脏健康和酒精成的恢复.
- 准肠道微生物组代表了治疗肝硬化和帮助戒酒的重大进展.
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