基于synchrotron的质子和基于linac的电子超高剂量速率辐射之间的急性胃肠道毒性不一致
bioRxiv : the preprint server for biology
|September 16, 2024
概括
与传统的质子相比,基于同步子的质子FLASH辐射在小鼠中增加了胃肠道毒性. 这凸显了了解质子FLASH疗法的安全临床转化因素的必要性.
科学领域:
- 辐射瘤学 辐射瘤学
- 医学物理 医学物理
- 放射生物学的放射生物学
背景情况:
- 使用超高剂量速率 (UHDR) 的质子FLASH放射疗法显示,它有望减少正常组织的毒性.
- 之前的调查主要使用循环旋和同步旋光束线,来自同步旋源的数据有限.
研究的目的:
- 评估剂量速率 (UHDR与传统) 和光束配置 (透射与扩散-布拉格峰) 对使用基于同步子质子的急性辐射诱导胃肠道毒性 (RIGIT) 的影响.
- 为了在匹配的平均剂量速率下,在基于同步子的质子和基于linac的电子之间进行RIGIT比较.
主要方法:
- 雌性C57BL/6J小鼠接受了腹部照射 (12-14 Gy单片) 使用87 MeV同步子质子束线.
- 剂量速度有所不同:常规 (0.2-0.3 Gy/s) 和FLASH (150-230 Gy/s),具有射入式和SOBP配置.
- RIGIT的评估是通过结核密室再生和生存分析,与电子辐射 (传统和FLASH) 的比较进行评估.
主要成果:
- 与传统的质子 (pCONV) 和传统的电子 (eCONV) 相比,质子闪光 (pFLASH) 导致再生状密室数量最低,表明毒性更高.
- 电子闪电 (eFLASH) 显示出再生密室数量最多,这表明它具有保护作用.
- 幸存率在pFLASH SOBP组中最低 (50%),在pCONV S-T组中最高 (100%),观察到显著差异.
结论:
- 与传统的质子辐射相比,基于同步离子的质子FLASH辐射显示了RIGIT的增加.
- 与基于Linac的电子辐射相比,观察到一种潜在的负质子特异性FLASH效应.
- 了解物理和生物因素对于基于同步离子的质子FLASH疗法的安全和有效的临床转化至关重要.
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