人类大脑的下一代组织学图书馆及其应用于自动脑MRI细分的应用
Adrià Casamitjana1,2, Matteo Mancini1,3,4, Eleanor Robinson1
1Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom.
bioRxiv : the preprint server for biology
|September 16, 2024
概括
下一个大脑是全人类大脑的第一个概率组织学图书馆,可以进行详细的MRI分析. 这本新的地图和人工智能工具加速了对大脑解剖学和疾病的理解.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 计算生物学 计算生物学
背景情况:
- 数字大脑地图对于分析人类大脑磁共振成像 (MRI) 数据至关重要.
- 现有的高分辨率组织学图谱缺乏概率标签,无法进行全面的全脑分析.
- 需要先进的工具来对不同受试者进行细分和比较神经解剖学.
研究的目的:
- 为了介绍NextBrain,这是一个由串行3D组织学衍生出来的人类大脑解剖学的新概率图谱.
- 开发人工智能驱动的技术,用于重建组织学数据和划分感兴趣的解剖区域 (ROI).
- 通过使用NextBrain图谱,为脑MRI扫描的自动细分提供辅助工具.
主要方法:
- 使用人工智能与联合几何约束来重建约10,000个组织学部分成3D卷.
- 在多个全脑半球中半自动追踪333个不同的解剖学ROI.
- 在体内和体外MRI扫描中开发用于自动化ROI细分的贝叶斯工具.
主要成果:
- 创建了全人类大脑的第一个概率组织学图书馆.
- 在脑MRI扫描中成功对333个ROI进行自动细分.
- 在超高分辨率的MRI细分和分析大脑衰老和阿尔茨海默病的应用的演示.
结论:
- 下一个大脑提供了详细的概率图谱和细分工具,推进了人类大脑MRI分析.
- 该地图使研究人员能够分析脑部MRI扫描,具有卓越的颗粒度和减少手工劳动.
- 下一个大脑有望提高MRI的发现特异性,并加快对大脑健康和疾病的研究.
相关概念视频
01:30Organization of the Brain
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
01:14Brain Imaging
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).