相关实验视频

Updated: Jun 13, 2025

Author Spotlight: Investigating the Motion Dynamics of the Eukaryotic Replisome Components at the Single-Molecule Level
10:11

Author Spotlight: Investigating the Motion Dynamics of the Eukaryotic Replisome Components at the Single-Molecule Level

Published on: July 26, 2024

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USP37 防止通过 MCM 复杂的 deubiquitination 进行非预定的复杂体卸载

Derek L Bolhuis1,2, Dalia Fleifel1, Thomas Bonacci2

  • 1Department of Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

bioRxiv : the preprint server for biology
|September 16, 2024
PubMed
概括

人类USP37通过对CMG螺旋酶进行二基因化,防止过早的复制体分解. 这保证了基因组的稳定性和正常细胞周期的进展,提供了潜在的癌症治疗目标.

关键词:
在CMG中,CMG是CMG.复制DNA复制DNA复制DNA复制基因组的完整性 基因组的完整性一些重复的重复.在任何地方都是无处不在的.

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