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老年小鼠更快地获得了静脉注射阿片类药物自给药,对摄入量有不同的影响
Amanda L Sharpe1, Laci R Liter2, Darius Donohue3
1Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences.
bioRxiv : the preprint server for biology
|September 16, 2024
概括
较老的小鼠对阿片类药物滥用的脆弱性增加,比较年轻的小鼠更快地学会自给自取雷米芬坦尼尔和芬太尼. 这表明老年人群中阿片类药物使用障碍的风险更高.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 药理学 药理学是指药理学的学科.
背景情况:
- 在老年人中,阿片类药物的使用,过量服用和使用障碍正在迅速增加.
- 对于健康的老年人群中阿片类药物滥用潜力的理解有限.
- 技术上的挑战阻碍了对老老鼠静脉药物自给药的研究.
研究的目的:
- 为了研究老年和年轻小鼠之间阿片类药物 (雷米芬坦尼尔和芬太尼尔) 自给药的年龄相关差异.
- 解决有关老年人群中阿片类药物滥用潜力的文献的关键差距.
- 为了比较年轻小鼠与老小鼠对阿片类药物的获取,摄入和暗示反应.
主要方法:
- 雄性和雌性小鼠被分为年轻的 (19周) 和老的 (101周).
- 训练小鼠在每日一次会议中静脉自给药芬太尼或雷米芬太尼.
- 测量了获取,摄入,戒断后的暗示反应,剂量反应和剂量升级曲线.
主要成果:
- 老老鼠学会了比年轻小鼠更快,更准确地自我注射remifentanil和fentanyl.
- 与年轻小鼠相比,老小鼠的基线雷米芬坦尼尔摄入量明显高于年轻小鼠.
- 老老鼠在戒断后对Remifentanil相关线索的反应有更大的潜伏期,与芬太尼不同.
结论:
- 与年轻人相比,老年人群可能对阿片类药物滥用有更大的脆弱性.
- 这些发现强调了研究与年龄相关的阿片类药物脆弱性增加背后的机制的重要性.
- 进一步的研究对于了解和减轻老年人阿片类药物风险至关重要.
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