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Updated: Jun 13, 2025

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase
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Published on: April 29, 2010

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Nsp1 阻断了 DNA 聚合酶 α 在 DNA 发针上

Andrey G Baranovskiy1, Lucia M Morstadt1, Nigar D Babayeva1

  • 1Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center. University of Nebraska Medical Center, Omaha, NE, USA.

bioRxiv : the preprint server for biology
|September 16, 2024
PubMed
概括

SARS-CoV-2 Nsp1 蛋白质通过阻断DNA聚合酶α (Polα) 在发针结构上抑制人类DNA复制. 这种相互作用与RPA竞争,影响感染期间的DNA合成.

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