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Updated: Jun 13, 2025

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一个突特异性的轴突支 de novo 质生成

Zhigang Xie, Adrija Pathak, Vytas A Bankaitis

    bioRxiv : the preprint server for biology
    |September 16, 2024
    PubMed
    概括

    扩散性内在庞丁质瘤 (DIPG) 是致命的儿科脑癌. 研究人员确定了三生根进入区域作为一个庞丁基,当特定突变存在时驱动DIPG形成.

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    In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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