在脊椎关节炎的并发症中性别和性别差异:专注于牛皮关节炎
F Atzeni1, C Siragusano1, A Tropea1
1Rheumatology Unit, Department of Experimental and Internal Medicine, University of Messina.
Reumatismo
|September 16, 2024
概括
牛皮关节炎 (PsA) 患者的心血管风险在中风或心肌梗塞等重大事件中没有显著的性别差异,尽管PsA的整体风险较高. 个性化医疗应考虑性别方面,以更好地管理并发症.
科学领域:
- 类风湿病学 类风湿病学
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 牛皮关节炎 (PsA) 是一种炎症性疾病,与一般人群相比,与心血管 (CV) 风险增加有关.
- 在PsA中,这种心血管风险增加归因于传统心血管风险因素,慢性系统性炎症和潜在的药物副作用的结合.
研究的目的:
- 在患有牛皮关节炎的患者中审查和评估心血管风险因素和疾病的潜在性别差异.
主要方法:
- 对调查牛皮关节炎患者心血管风险因素和结果的研究进行系统审查.
- 分析可用的性别分层数据,以确定男性和女性患者之间的潜在差异.
主要成果:
- 关于PsA群体内心血管风险因素的性别差异现有研究产生了有争议的结果.
- 报告性别分层数据的有限研究发现,在PSA患者中,中风,心肌梗塞或心血管死亡率的风险在性别之间没有显著差异.
- 研究设计,病例定义和人口遗传学/地理学的变化可能导致混合结果.
结论:
- 评估与PsA相关的心血管并发症中的性别和性别对于推进个性化医学的发展至关重要.
- 根据性别考虑量身定制预防和治疗策略,可以改善对PsA相关并发症的管理.
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